We review brain health supplements the way they should be reviewed — with peer-reviewed research, honest ratings, and zero hype. Because your cognition is too important for guesswork.
We analyze the clinical evidence so you don't have to. Each supplement rated by the strength of its research — not marketing budgets.
Both a choline donor for acetylcholine synthesis and a precursor to phosphatidylcholine for neuronal membranes. Backed by a Cochrane review of 13 studies and multiple meta-analyses.
The deepest evidence base of any brain supplement. A 2025 meta-analysis of 58 RCTs found 2,000 mg/day significantly improved attention, memory, and global cognition.
One of the best-studied herbal nootropics. A meta-analysis of 9 RCTs showed improved speed of attention and cognition. Requires 12+ weeks for effects.
Not just for muscles. A 2024 meta-analysis found improved memory, processing speed, and attention. Greatest benefits in vegetarians, elderly, and sleep-deprived individuals.
Stimulates nerve growth factor (NGF) production via hericenones and erinacines. Promising mechanisms, but human trials remain small and results are mixed.
A 2024 meta-analysis of 9 RCTs confirmed significant stress and anxiety reduction. Improves recall memory, lowers cortisol, and enhances sleep quality.
Citicoline isn't just another nootropic — it's one of the few brain supplements with a Cochrane review, multiple meta-analyses, and a clean safety profile across decades of clinical use.
As both a choline donor for acetylcholine production and a direct precursor to phosphatidylcholine in neuronal membranes, citicoline works through two complementary mechanisms that most supplements can't match.
No paid placements. No cherry-picked studies. Every rating follows the same rigorous four-step process.
We search PubMed, Cochrane, and clinical trial registries for all available human evidence — prioritizing meta-analyses and systematic reviews over isolated studies.
Each supplement gets a 5-tier evidence rating per claimed benefit. We separate what's proven from what's promising from what's purely speculative.
Content is reviewed by qualified health professionals for accuracy, appropriate context, and responsible health claims before publication.
Science moves fast. We monitor new publications and update our ratings and recommendations as stronger evidence emerges — including downgrading when warranted.
Deep dives into the science of cognitive health — from supplement research to lifestyle strategies that protect your brain.
Everything you need to know about CDP-choline — the brain supplement backed by a Cochrane review and decades of clinical research.
A landmark 2025 meta-analysis identified the optimal dose range for cognitive benefits. Here's what it means for your supplement routine.
A 2024 meta-analysis confirmed what researchers suspected — creatine significantly improves memory and processing speed, especially in specific populations.
Proprietary blends, fairy-dusted doses, and unverified claims — learn to spot the difference between legitimate supplements and expensive placebos.